ParkinsonCanadaV1, Main, Exploration, bibRecord, 001518

Hypoxia regulation of ATP13A2 (PARK9) gene transcription

Identifieur interne : 001518 ( Main/Exploration ); précédent : 001517; suivant : 001519

Hypoxia regulation of ATP13A2 (PARK9) gene transcription

Auteurs : QIAN XU [Canada, République populaire de Chine] ; HONGLING GUO [Canada] ; XIAOJIE ZHANG [Canada] ; BEISHA TANG [République populaire de Chine] ; FANG CAI [Canada] ; WEIHUI ZHOU [République populaire de Chine] ; WEIHONG SONG [Canada, République populaire de Chine]

Source :

Journal of neurochemistry [ 0022-3042 ] ; 2012.

RBID : Pascal:12-0295770

Descripteurs français

Pascal (Inist)
- Hypoxie, Gène, Transcription, Mutation, Génétique, Protéine, Expression génique, Promoteur transcription, Maladie de Parkinson, Elément réponse, Facteur transcription, Trouble moteur, Transduction signal, Pathogénie, Homme, Oxygène.
Wicri :
- topic : Génétique, Homme, Oxygène.

English descriptors

KwdEn :
- Gene, Gene expression, Genetics, Human, Hypoxia, Motor system disorder, Mutation, Oxygen, Parkinson disease, Pathogenesis, Protein, Response element, Signal transduction, Transcription, Transcription factor, Transcription promoter.

Abstract

Parkinson's disease (PD) is the second most common neurodegenerative disorders with a variable combination of motor and non-motor symptoms. Mutations in several genes including ATP13A2 (PARK9) are reported to be associated with PD. The underlying mechanism of PD is not well defined, however, both genetic and environmental causes contribute to it. ATP13A2 gene locates in chromosome 1 and contains 29 exons encoding for a protein of 1180 amino acids with 10 transmembrane domains. Abnormal gene expression has been implicated in neurodegenerative disorders. The transcriptional regulation of the ATP13A2 gene is unknown. In this report, we cloned and functionally characterized the human ATP13A2 gene promoter. We showed that the promoter region of the human ATP13A2 gene contains hypoxia response elements which can bind to transcription factor hypoxia-inducible factor 1α (HIF-1α). Hypoxia up-regulated ATP13A2 transcription via HIF-1α in HEK293 and dopaminergic MN9D cells. Our study indicates that hypoxia signaling plays a very important role in the regulation of human ATP13A2 gene expression. Further study is needed to determine the role of hypoxia in the pathogenesis of PD and its interaction with other PD causative genes, which will provide insights to the role of hypoxia and dysregulation of gene expression in Parkinson's disease.

Affiliations:

Canada, République populaire de Chine

Links toward previous steps (curation, corpus...)

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Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Gene</term>
<term>Gene expression</term>
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<term>Human</term>
<term>Hypoxia</term>
<term>Motor system disorder</term>
<term>Mutation</term>
<term>Oxygen</term>
<term>Parkinson disease</term>
<term>Pathogenesis</term>
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<term>Expression génique</term>
<term>Promoteur transcription</term>
<term>Maladie de Parkinson</term>
<term>Elément réponse</term>
<term>Facteur transcription</term>
<term>Trouble moteur</term>
<term>Transduction signal</term>
<term>Pathogénie</term>
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<front><div type="abstract" xml:lang="en">Parkinson's disease (PD) is the second most common neurodegenerative disorders with a variable combination of motor and non-motor symptoms. Mutations in several genes including ATP13A2 (PARK9) are reported to be associated with PD. The underlying mechanism of PD is not well defined, however, both genetic and environmental causes contribute to it. ATP13A2 gene locates in chromosome 1 and contains 29 exons encoding for a protein of 1180 amino acids with 10 transmembrane domains. Abnormal gene expression has been implicated in neurodegenerative disorders. The transcriptional regulation of the ATP13A2 gene is unknown. In this report, we cloned and functionally characterized the human ATP13A2 gene promoter. We showed that the promoter region of the human ATP13A2 gene contains hypoxia response elements which can bind to transcription factor hypoxia-inducible factor 1α (HIF-1α). Hypoxia up-regulated ATP13A2 transcription via HIF-1α in HEK293 and dopaminergic MN9D cells. Our study indicates that hypoxia signaling plays a very important role in the regulation of human ATP13A2 gene expression. Further study is needed to determine the role of hypoxia in the pathogenesis of PD and its interaction with other PD causative genes, which will provide insights to the role of hypoxia and dysregulation of gene expression in Parkinson's disease.</div>
</front>
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	La maladie de Parkinson au Canada (serveur d'exploration)
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La maladie de Parkinson au Canada (serveur d'exploration)

Hypoxia regulation of ATP13A2 (PARK9) gene transcription

Hypoxia regulation of ATP13A2 (PARK9) gene transcription

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri